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Nitromidazoles by A. Breccia

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Published by Plenum Pub Corp .
Written in English


  • Pharmacodynamics,
  • Adjuvant treatment,
  • Cancer,
  • Congresses,
  • Nitroimidazoles,
  • Physiological effect,
  • Testing

Book details:

Edition Notes

Nato a S I Series Series a, Life Sciences

The Physical Object
Number of Pages211
ID Numbers
Open LibraryOL10323134M
ISBN 10030640916X
ISBN 109780306409165

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In July , the Faculty of Pharmacy of the University of Bologna received a proposal from Professor Breccia to hold an International Conference on "Nitroimidazoles: Chemistry, Pharmacology and Clini. ISBN: OCLC Number: Description: 1 online resource: Contents: The Pharmacology and Toxicology of 5-Nitroimidazoles --Nitroimidazole Chemistry I. Synthetic Methods --Chemical Properties and Reaction Mechanisms of Nitroimidazoles --In vivo Testing of Radiosensitizers --Nitroimidazoles as Hypoxia-Mediated Drugs . Nitroimidazoles Conference papers and proceedings Congresses: Additional Physical Format: Online version: NATO Advanced Study Institute on Radiosensitizers of Hypoxic Cells ( Cesanatico, Italy). Nitroimidazoles. New York: Plenum Press, © (OCoLC) Material Type: Conference publication: Document Type: Book: All Authors.   Infectious diseases claim millions of lives every year, but with the advent of drug resistance, therapeutic options to treat infections are inadequate. There is now an urgent need to develop new and effective treatments. Nitroimidazoles are a class of antimicrobial drugs that have remarkable broad spectrum activity against parasites, mycobacteria, and anaerobic Gram-positive and Gram .

Abstract. 5-Nitroimidazoles are highly effective therapeutic agents (1) against a variety of anaerobic bacteria and protozoa (Table 1). For this reason, the medicinal use of these agents has been explored in humans and in food-producing animals. 1‐Triphenylmethylimidazoles are treated with n‐butyllithium in tetrahydrofuran at 0° to form the 2‐lithio latter species react with n‐propyl nitrate to give l‐trityl‐2‐nitroimidazoles which, after acid hydrolysis, provide the corresponding 2‐nitroimidazoles. 2‐Nitroimidazole was obtained from imidazole in overall yields of 27–35% 4‐methyl‐2. The 5-nitroimidazoles are a group of drugs that have both antiprotozoal and antibacterial activity. Nitroimidazoles with activity against trichomonads and amebae include metronidazole, tinidazole, nimorazole, flunidazole, and ronidazole. Metronidazole and nimorazole are effective in treatment of giardiasis, whereas dimetridazole, ipronidazole, and ronidazole control histomoniasis in poultry. 5-Nitroimidazole is an organic compound with the formula O 2 NC 3 H 2 N 2 H. The nitro group at position 5 on the imidazole ring is the most common positional term nitroimidazole also refers to a class of antibiotics that share similar chemical structures. Synthesis. Imidazole undergoes a nitration reaction with a mixture of nitric acid and sulfuric acid to give 5-nitroimidazole.

Use of the information, documents and data from the ECHA website is subject to the terms and conditions of this Legal Notice, and subject to other binding limitations provided for under applicable law, the information, documents and data made available on the ECHA website may be reproduced, distributed and/or used, totally or in part, for non-commercial purposes provided that ECHA is.   Nitromidazoles, nitrofurans, streptogramins Drugs 1. PHAR LECTURE 8 NITROMIDAZOLES, NITROFURANS, STREPTOGRAMINS Antimicrobial agents and Immunization 2. Nitroimidazoles Gram positives, Gram negatives, protozoa, . Stanley L. Marks, in August's Consultations in Feline Internal Medicine, Volume 7, Treatment. A nitroimidazole drug, ronidazole, is the drug of choice for the treatment of T. blagburni in cats. 19 The dosage is 30 mg/kg orally (PO) once a day for 14 consecutive days. In a retrospective study of cats infected with T. blagburni, 64% of cats treated with ronidazole had a good response. 2-Nitroimidazoles also can cause DNA damage by enzyme-driven redox cycling of the nitro functional group. , In this process, single-electron enzymatic reduction of the nitro group yields a radical anion that can be oxidized by molecular oxygen to generate superoxide radicals and regenerate the starting nitro compound (Scheme 22).Although enzyme systems protect cells from its deleterious.